Knowtex

L’Anses a été saisie pour la réalisation de l’expertise suivante : Analyser les éléments présentés dans la monographie du Centre international de recherche sur le cancer (CIRC) sur le glyphosate et dans les rapports d’expertise de l’État membre rapporteur […]

After 40 years of use, and multiple regulatory approvals including toxicology evaluations, literature reviews, and numerous human health risk assessments, the conclusions are that glyphosate is of low toxicological concern, and no concerns exist with respect to its use and cancer in humans.

That report contains comments on the compounds considered, acceptable daily intakes established by the WHO Core Assessment Group, and maximum residue limits established by the FAO Panel of Experts. Monographs on residues are published as a companion volume, Evaluations 2004, Part I, Residues.

The present review of subsequent genotoxicity publications and regulatory studies of glyphosate and glyphosate-based formulations (GBFs) incorporates all of the findings into a weight of evidence for genotoxicity.

Over four decades, a WHO research agency has assessed 989 substances and activities, ranging from arsenic to hairdressing, and found only one was “probably not” likely to cause cancer in humans. It was an ingredient in nylon used in stretchy yoga pants and toothbrush bristles.

Glyphosate has become the dominant herbicide worldwide. There are several reasons for its success. Glyphosate is a highly effective broad- spectrum herbicide, yet it is very toxicologically and environmentally safe. It translocates well, and its action is slow enough to take advantage of this.

Le texte suivant est le premier d'une série de trois dans laquelle nous examineront comment une campagne contre un produit agricole essentiel réussit dans l'Union européenne. Cette première partie se penchera sur les raisons pour lesquelles le glyphosate est un bon produit pour les agriculteurs.

The toxicokinetics of glyphosate after single intravenous (i.v.) and oral doses were studied in rats. After oral administration, glyphosate was partially and slowly absorbed with a T(max) of 5.16 h. Glyphosate was converted to AMPA, whose elimination half-life (T(1/2beta)) was 15.08 h.

Rats were orally administered a mixture of glyphosate at a dose level of 10 mg/kg body weight. The results from this study indicate that virtually no toxic metabolites of glyphosate were produced.

European Food Safety Authority (EFSA) concluded that glyphosate is unlikely to pose a carcinogenic hazard to humans and the evidence does not support classification with regard to its carcinogenic potential according to Regulation (EC) No 1272/2008.