Knowtex

The toxicokinetics of glyphosate after single intravenous (i.v.) and oral doses were studied in rats. After oral administration, glyphosate was partially and slowly absorbed with a T(max) of 5.16 h. Glyphosate was converted to AMPA, whose elimination half-life (T(1/2beta)) was 15.08 h.

Rats were orally administered a mixture of glyphosate at a dose level of 10 mg/kg body weight. The results from this study indicate that virtually no toxic metabolites of glyphosate were produced.

This review was undertaken to produce a current and comprehensive safety evaluation and risk assessment for humans. It includes assessments of glyphosate, its major breakdown product (AMPA), its Roundup formulations, and the predominant surfactant (POEA) used in Roundup formulations worldwide.